Transplants are a staging Biomedical Feet, which has become so accessible and simple that they make the news just because there is a first-of-its-type breakthrough. Despite the lips and bounds made with the procedures, rejection of the organ or texture of the body's immune response remains a huge hurdle.
As reported in the journal Advanced Materials, A group of scientists can cook a solution to the problem. Research from Tel Aviv University in Israel has invented new technology that allows them to completely personalized texture implants using a self-contained cell and biomaterials.
"The implants will not be denied by the body," Professor Tal Dvir of Tel Aviv University's Center for Nanoscience said in A statement.
"Since both the cells and the material used by the patient, the implants do not challenge an immune response, which ensures the correct regeneration of the defective organ."
Remarkably, the method allows researchers to engineers any type of tissue implants of only a small fatty tissu biopsy. To do this, they first rejected cells from the patients of the patient, and they "reprogrammed" them to become implicit pluripotent stem cells – "master cells" that have the capacity to develop in all tissue cells in the human body. Next, Biopsy's extracellular material was fashioned in a personalized hydrogel. With the two major components, the scientists have successfully engineered personalized tissue samples.
"We are able to create a personalized hydrogel of the biopsy materials, to cause fatty tissue cells in different cell types and inserter cardiac, spinal cord, cortical and other tissue implants to treat different diseases," he adds.
A similar method is now available using synthetic materials or cells derived from animal or plants. However, after transplantation, patients are required to take hops from immunosuppressant drugs, which bring their own dangers, and are faced with the high risk of an immune response that leads to the rejection of the implanted tissue.
While the team has not transplanted the personalized tissues in a human body, very early experiments on animals and in vitro human samples suggest that the body response response will be minimal.
So far, they have managed to successfully operate functional cardiac, spinal cord, coral, and adipogenic tissue. They also work on the regeneration of an injured spinal cord and an infected heart with spinal cord and cardiac implants. Further down the line, they hope to regenerate other organs using a self-contained cell, such as intestines and eyes.
"With our technology, we can engineer any type of tissue, and after transplantation we can efficiently regenerate any ill or injured organ – a heart after a heart attack, a brain after traumatic or parinsonon's disease, a spinal cord after injury," adds Prof. Dvir.