JERUSALEM, November 12 (Xinhua) – Israeli researchers have developed a method for making human tissues for transplant from the small fat tissue of the patient himself, the Tel Aviv University said on Monday.
The method allows the patient's personal tissue in the body without risking the rejection of the immune system.
So far, there are some synthetic or animal substances that cause an immune response in the patient, therefore immunosuppressive medications are required.
In tissue engineering, synthetic or biological polymers are used as extracellular materials, which support cells and enable the formation of functional tissues.
So far, extracellular material, now considered the best for transplantation, is taken from pig tissue. All the pig cells are removed in the process, while the remaining material is growing human cells.
However, the extracellular material of the pig causes a severe immune response, which may lead to a rejection of the implant. The patient should continue to take drugs, sometimes for a life that would suppress his immune system.
In order to find a solution, the investigators with the minimal invasive procedure removed the fat tissue of the patient, separated cells from extracellular material and created an adapted gel for the patient.
Then the fat cells were "reprogrammed" into the pluripotent stem cells, which can be converted into all types of cells.
Thus, the researchers succeeded in producing tissue for repairing spinal cord injury and treating damaged heart muscle, neural tissue for Parkinson's patients and fat tissue for reconstructive surgery.
Because the tissue originates from the patient, they will not trigger an immune response. This technology has been successfully tested on animals and human immune cells.