Discovering a serious link between the additive and Parkinson's disease: a big step forward



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The appendix affects Parkinson's disease. These are summaries and hypotheses supported by neuroscientists from around the world who started a large study of nearly 1.7 million patients. The study was published in the journal Science Translation Medicine, which shows that patients who have eliminated the additive have up to 25% less chance of being affected by Parkinson's disease.

Obvious connections

Parkinson's disease, named after James Parkinson and described in 1817, is the second most common neurodegenerative disorder after Alzheimer's disease. Also known as an aging disease, it starts around 45 years and can be reported in the next 30 years. It is a degenerative chronic neurological disease, a progressive loss of the brain that causes the lack of dopamine in some brain structures. This affects the central nervous system (responsible for progressive disorders: slow movements, trembling, stiffness and cognitive disorders). His causes remain unknown, although there is considerable evidence that the bowels are partly responsible for this.

Today, we know that Parkinson's disease develops in the gut by using nerves to return to the brain. A fact that is not surprising, since one of the first symptoms of the disease is constipation. Researchers also observed that the protein, alpha-synuclein (a protein that is closely related to the disease), is in the form of abnormal lumps in the gastrointestinal tract. Viviane Labrie, the lead author of the study, explains that " although its reputation (additive) is largely "useless", the additive actually plays an important role in our immune system in regulating the composition of intestinal bacteria and now, as it points to our work at the onset of Parkinson's disease"Here we understand that alpha-synuclein protein accumulates in the intestine after an immune reaction to toxins and bacteria.

Nevertheless, this is a difficult explanation that should be retained as the main cause of Parkinson's disease. Because it is a slower disease, it takes years to find that dopamine cells are degraded to the point where the body experiences tremor or stiffness of the muscles. However, researchers believe that the brain cell is associated with damage to how alpha-synuclein is inhibited and agglomerated by some people. In addition, it can be observed that accumulation of this protein has become increasingly important in recent decades, which leads to worrying brain-intestinal interactions. It provides solid evidence, but it is still a fact that slow progression of the disease in people that you think are at risk is better. This makes it difficult to obtain study results and interpretation for people who initially do not pose a risk.

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Towards a better understanding of the causes?

Recently, this study was conducted by neuroscientists around the world who supported two hypotheses about the likely causes of Parkinson's disease. For this, they have linked details about PPMI (Parkinson's Progressive Marking Initiatives); is an observational clinical study that comprehensively evaluates important cohorts of interest with advanced images, biological sampling techniques, and clinical and behavioral assessments to identify biomarkers in the progression of Parkinson's disease. And a record of the Swedish National Patient Register with a view to finding possible links between neurodegenerative diseases and appendectomies.

An extensive study, focusing on monitoring nearly 1.7 million people, shows a difference that is almost 20% less likely to be prone to Parkinson's disease among patients with no additive and those with an additive intact. Even better, the researchers also pushed the comparison into patient dwellings between urban and rural areas, and they noted that the difference was reduced by 25% less fortunate for people who did not have more Appendix.

The study in no way proves that removal of the additive will become immune to this disease, but adds new insights into the causes of Parkinson's disease. according to which Vanessa Fleury, a neurologist at the University Hospital in Geneva, "This study supports two hypotheses: Parkinson's disease begins early in the digestive tract; environmental factors such as exposure to pesticides play a role in the emergence of pathology into genetically modified persons."

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