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In a study in mice, the researchers found that their strongest peptide could completely eliminate pseudomonas aeruginosa, a strain of bacteria that causes respiratory and other infections, and resistant to most antibiotics.
In a study in mice, researchers found that Its stronger peptide can completely eliminate Pseudomonas aeruginosa, A strain of bacteria that casts respiratory and other infections, and is resistant to most antibiotics.
"We have rebuild a toxic molecule in one that is a viable molecule to treat infections," he says. César de la Fuente-Núnez, One of the authors of the article published in the journal Nature Communications Biology. "By systematically analyzing the structure and function of the peptides, we have been able to adjust their properties and activity," he continues.
The venom of insects such as wasps and bees is full of compounds that can kill bacteria, but which are too toxic to humans. To help combat the eyes of bacteria resistant to antibiotics, many scientists have been trying Adopt the peptides as new potential drugs.
The peptides that the La Fuente-Nñu and his colleagues were focusing on the study Isolated from a wasp known as Polybia Paulista. The team chose the most promising compounds to test in mice infected with pseudomonas aeruginosa, a common source of respiratory and urinary tract infections, and found that some of the peptides could reduce infection. One of them, additions to a high dose, can eliminate it completely.
"After four days, That compound can eliminate infection completelyAnd this is quite surprising and exciting because we do not usually see that with other experimental antimicrobials or other antibiotics that we have tried in the past with this particular mouse model, "says De la Fuente Núñez.
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