They find a link between the additive and Parkinson's disease


11.5.2018 – The links between Parkinson's disease and gastrointestinal tract are known. Now, a group of scientists have found a link with an attachment that adds new tracks to research on the origin of this disorder.

According to a study published today in Science Translational Medicine, a person who had the additive was removed from the young, among adult patients was between 19% and 25% lower risk of Parkinson's disease.

"Our results point to the addition as a source of Parkinson's disease and provide a way to create new treatment strategies that exploit the role of the gastrointestinal tract in the development of the disease," said lead author Viviane Labrie of the Van Andel Research Institute in Michigan, USA.

Why? A look at the tissue of the extracted additive shows that this small organ, often unusable, looks like a reservoir of abnormal protein (an abnormally folded alpha-synuclein), which becomes the central feature of the disease if it reaches the brain. Parkinson.

A great surprise, according to the results of the work, is that many people may have concentrations of this worrying protein in their chests: young and old, people with healthy brain and Parkinson's disease.

But do not rush the surgeon.

"We do not say that this is an appendectomy," said a neuroscientist and geneticist who led a team of researchers who analyzed data from two large-scale epidemiological studies, one of 1.6 million people and the other 91 million. .

After all, many people without organs eventually develop Parkinson's and others who have proteins never get sick, the article writes.

Risk reduction has become apparent only if the additive and alpha-synuclein contained in it were excluded at an early age, years before the onset of the disease, indicating that the organ could participate in its onset. Her removal after the onset of the disease did not affect his progression.

In the general population, people with appendectomy had a 19% less chance of developing Parkinson's disease, which increased in people living in rural areas with a 25% reduction in the risk of developing the disease. On the contrary, the interventions did not have obvious benefits in humans whose disease was associated with genetic mutations transmitted by their families, a group of less than 10% of cases.

The efforts of the scientific community are focused on understanding the origin of this disorder so that it can be treated early, as patients now come to the office when disorders such as tremor or stiffness occur, a sign that the disease has already progressed.

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Doctors and patients have known for a while that there is a link between the gastrointestinal tract and Parkinson's disease. Closing and other problems in the lungs are common in humans, which then begin to confront tremors and other problems in the movement that lead to diagnosis of the disease.

A recent survey will encourage new research to try to find new clues to find out why and who are really at risk.

"It's a piece of a jigsaw puzzle, basic concepts," said dr. Allison Willis, a specialist in Parkinson's University of Pennsylvania, who was not included in the new study, but says her patients regularly ask about gastrointestinal contacts.

The chief scientist of Parkinson's disease, James Beck, who was not involved in the study, also said that "there are many promising links".

He noted that, despite his reputation, the supplement has the role of immunity that could affect inflammation. The types of bacteria living in the additive may also affect Parkinson's disease.

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