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Santiago de Chile, Dec 9 (EFE) .- A team of Chilean researchers has promoted advances in the fight against Alzheimer's, after discovering a relationship between activating a brain pathway and the correct metabolism of sugars in the brain.
The work, carried out by doctors Nibaldo Inesstrosa and Pedro Cisternas, from the Center for Senior and Regeneration of the Catholic University (CARE Chile UC), and developed in animal models, managed to improve the cognitive capacity and memory in mice and was released recently In the Journal Neurochemistry, according to the EF researchers reported.
Humor, sense and sense of humor are cognitive abilities that require a high energy consumption in the brain and the correct handling of sugars in that organ can now be malleable in a laboratory, thanks to the study.
The researchers are able to determine the importance of activating a brain pathway called WNT in the glucose metabolism, a fundamental process for neurons and brain activity.
The experiments, developed in transnational animal models, specifically seek to slow down or slow down Alzheimer's, the most commonly used age, affecting some 18 million people in the world and is the fourth cause of death on the planet.
The research indicates that the activation of the VN pathway stimulates glucose metabolism, particularly in neurons, a very important process in the brain, an organ that needs a lot of glucose and energy for its proper functioning, especially in regions related to memory processes And study, such as the cortex and the Hippocampus, "explains Dr. Sisteras.
The brain, he said, represents 2% of body weight, but needs about 20% oxygen and 25% of the human body (ATP).
The ATP, stressed cestern, is the energy molecule occupied salt for its vital functions and in the context, a significant aspect is that glucose metabolism is diminished in almost all neurodegenerative diseases such as Alzheimer's, Parkinson's and Hungtinton, which is linked to a Discount in the brain's ability to use glucose. "
At the same time, the WNT is a mechanism developed by proteins, which is associated with brain formation, synapses, interactions of neurons, and memory and research and research has explored its leading role in Alzheimer's and other failures, and some strategies To activate it.
The latter, in order to prevent injuries and recover communication between neurons.
Dr. Nibaldo Inestroza, National Science Prize, explains that in Alzheimer's neurons suffer from deterioration due to the accumulation of an insoluble protein as Beta Amoiloid, which interrupts the signaling function that communicates the neurons with each other.
In this context, it is possible to recover the relationship between brain cells and prevent injuries for all of this, for us it is essential to find compounds that activate it and which can be transformed into possible treatments to fight this Pathology, "he said.
"In our last publication we have said that when we activate the wine in our models, the cognitive response of the animals is improved, and glucose metabolism is adapted, in addition to all the features we have previously explored," he said.
However, "when at the same time we inflicted a glucose pharmacy inhibitor, this protective effect is lost, which means that the activation of the pathway promotes the improvement, but it is also dependent on the use of glucose and the generation of ATP."
Based on the background, researchers are developing different strategies to activate the WNT signaling pathway, in order to promote an improvement in the onset or progression of Alzheimer's disease.
"We want to create therapies of molecules that generate an activation of the pathway, and thus, project benefits for patients with Alzheimer's are the main reasons to delay memory loss, which can be of great impact for the affected and their family environment," said Said Dr. Sisteras EFE
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