Japanese researchers injected so-called "iPS" stem cells into the brain of a patient with Parkinson's disease. The purpose of this clinical trial is to test whether these cells can regenerate dopamine neurons and relieve symptoms.
Group teaminjected 2.4 million of these , which can be in any type of cell in the left part , in three hours last month. The man, in his fifties, was well tolerated and will now be under surveillance for two years now, according to a statement from the Kyoto University.
If no problem occurs in the next six months, additional 2.4 million cells will be implanted, this time in the right part of the patient's brain. It is expected that these IPS cells from healthy donors will growmanufacturers of dopamine, a neurotransmitter involved in engine monitoring.
In July, Kyoto University announced the holding of this clinical trial with seven participants aged 50 to 69 years. "I welcome patients for their courageous and determined participation", commented Professor Jun Takahashi, who was today published by NHK's public television channel.
Pluripotent cells for creating new neurons
is characterized by the degeneration of dopamine neurons and has results which are gradually worsening, such as shivers, stiffness of the limbs and reduction in body movement. This affects more than ten million people around the world, depending on USA. Currently, therapies are available "Improve symptoms without slowing down disease progression"explains the foundation.
This test follows an experiment that was performed on monkeys withof human origin, which have improved the ability to move a disease of Parkinson's disease, according to a study published late in August 2017 in a scientific journal nature. Survival of grafted cells by injection into the brain of primates has been observed for two years without .
(iPS for induced pluripotent stem cells), adult cells are returned to an almost embryonic state by expressing them four (usually inactive in adult cells). This genetic manipulation gives them the ability to produce all kinds (pluripotence) according to the site of the body, where they are then transplanted. The use of iPS cells does not represent fundamental ethical problems, unlike the source cells we take people.
What to remember
- Scientists from the University of Kyoto injected 2.4 million pluripotent cells into the patient's brain.
- These cells of healthy donors will have to restore the dopamine neurons.
- In total, the clinical trial should include seven patients.
Parkinson's disease: stem cells return to the monkeys
Article from Tokyo – AFP, published on February 25, 2012
Monkeys that develop the equivalentshowed improvement in their symptoms after injection into the stem cell brain. Techniques could be tested in humans from 2015.
Monkeys who suffer from Parkinson's disease have advanced considerably after implantation of human stem cells into the brain, Japanese researchers reported today.
Four monkeys whose limbs spasmodically moved (common symptomfor And those who fought to control their bodies showed signs of improvement three months after the operation, said Jun Takahashi, a professor at , one of the authors of the study, published in .
Six months afterThe four tested primates were able to walk again in their cage, he added.
Jun Takahashi stated that during the implementation of 35%were dopaminergic neurons, about one-tenth of them were still alive a year later. In order to improve the effectiveness of treatment, I would like to increase this survival rate to 70%. He hopes that this experiment can be done on people as early as 2015. " First, we need to increase the number of dopaminergic neurons , in order to reduce the risk " , he explained.
Pluripotent stem cells that occur in humans
Jun Takahashi and his team used this monkey experimentbut in the case of medical experience, researchers think they are using them (IPSC) arising from the implantation of four types of genes into human skin reprogramming cells. These induced iPSCs, which are thus generated, return almost to the embryonic stage (undifferentiated).
Use, which many scientists believe is very promising, contrary. Religious groups believe that the culture of these cells is unethical and emphasizes this . However, in Japan nothing prohibits the use of these cells for scientific research.
is one of the main ones by . This is also one of the most common causes of engine interference cerebrovascular disease.